Device and method for removing undesirable biological and/or chemical entities from biological fluids

A method for the ex-vivo removal of a biological and/or chemical entity (C) from an extracorporeal blood volume (B) comprising:

• a) introducing the extracorporeal blood (B) into a hollow capture chamber having a cylindrical shape, an inlet for the entry of the extracorporeal blood (B), an outlet for the outflow of the extracorporeal blood (B) and a capture element extending longitudinally within the capture chamber and movable relative to the capture chamber, the capture element:
• i) being rotatable about a longitudinal axis (a) of the capture chamber;
• ii) having a reactant surface for contacting the extracorporeal blood (B), said reactant surface comprising a plurality of binding agents (A) for the biological and/or chemical entity to be removed (C), and
• iii) a coupling and uncoupling system configured such that the capture element can be removed from the capture chamber to allow analysis of entities captured by the reactant surface,
• b) filtering the extracorporeal blood (B) by contact with the reactant surface having the plurality of binding agents (A) for the biological and/or chemical entity (C) to be removed;
• and
• c) extracting the extracorporeal blood (B) devoid of said biological and/or chemical entity (C) from the capture chamber;
• wherein the total volume of extracorporeal blood (B) flowing inside the capture chamber is between 3 to 30 liters of blood.