Three dimensional electrospun biomedical patch for facilitating tissue repair

A three-dimensional electrospun biomedical patch for facilitating tissue repair, the three-dimensional electrospun biomedical patch comprising:

• a first polymeric plurality of fibers making up a scaffold, the scaffold comprising a first structure of deposited electrospun fibers, the first structure of deposited electrospun fibers comprising a plurality of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the three-dimensional electrospun biomedical patch to a tissue, wherein the first period of time is less than twelve months;
• a second polymeric plurality of fibers making up the scaffold, the scaffold further comprising a second structure of deposited electrospun fibers, the second polymeric plurality of fibers overlaid on the first polymeric plurality of fibers, the second polymeric plurality of fibers comprising one or more portions with a higher deposition of fibers than one or more portions of the first polymeric plurality of fibers, the second structure of deposited electrospun fibers comprising the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue, wherein the second period of time is less than twelve months;
• the plurality of deposited electrospun fibers connecting the first polymeric plurality of fibers and the second polymeric plurality of fibers, the plurality of deposited electrospun fibers comprising a first set of deposited electrospun fibers generated by electrospinning a first polymer composition and a second set of deposited electrospun fibers generated by electrospinning a second polymer composition, wherein the first set of deposited electrospun fibers and the second set of deposited electrospun fibers are entangled, wherein the first set of deposited electrospun fibers and the second set of deposited electrospun fibers are bioresorbable;
• and
• a plurality of pores, the plurality of pores comprising one or more pores between 10 μm and 10 cm in length,
• wherein the three-dimensional electrospun biomedical patch is pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.

A three-dimensional electrospun biomedical patch for facilitating tissue repair, the three-dimensional electrospun biomedical patch comprising:

• a first polymeric plurality of fibers making up a scaffold, the scaffold comprising a first structure of deposited electrospun fibers, the first structure of deposited electrospun fibers comprising a plurality of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the three-dimensional electrospun biomedical patch to a tissue, wherein the first period of time is less than twelve months;
• a second polymeric plurality of fibers making up the scaffold, the scaffold further comprising a second structure of deposited electrospun fibers, the second polymeric plurality of fibers overlaid on the first polymeric plurality of fibers, the second polymeric plurality of fibers comprising one or more portions with a higher deposition of fibers than one or more portions of the first polymeric plurality of fibers, the second structure of deposited electrospun fibers comprising the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue, wherein the second period of time is less than twelve months;
• and
• the plurality of deposited electrospun fibers connecting the first polymeric plurality of fibers and the second polymeric plurality of fibers, the plurality of deposited electrospun fibers comprising a first set of deposited electrospun fibers generated by electrospinning a first polymer composition and a second set of deposited electrospun fibers generated by electrospinning a second polymer composition, wherein the first set of deposited electrospun fibers and the second set of deposited electrospun fibers are entangled, wherein the first set of deposited electrospun fibers and the second set of deposited electrospun fibers are bioresorbable wherein the plurality of deposited electrospun fibers are deposited in an arrangement comprising a plurality of void slits between 10 μm and 10 cm in length;
• wherein the three-dimensional electrospun biomedical patch is pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.