Myocyte-derived flow assist device: extravasal sheaths of rhythmically contracting myocytes aiding flow of biological fluids
AssigneeThe George Washington University a Congressionally Chartered Not-for-Profit Corporation
InventorNarine Sarvazyan
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Abstract
This invention relates, e.g., to a Myocyte-based Flow Assist Device (MFAD) for treating a subject in need of increased flow of a biological fluid, such as venous blood or lymph, comprising a sheath which comprises rhythmically contracting myocytes.
Claims15
A Myocyte-based Flow Assist Device (MFAD) for treating a subject in need of increased flow of biological fluids, comprising:
- a vessel segment;
- and
- a sheath which comprises rhythmically contracting myocytes, the sheath disposed on at least a portion of a surface of the vessel segment,
- wherein the sheath further comprises at least one sheet of myocytes formed into a ring, and
- wherein the sheath further comprises a scaffold, within which are embedded the rhythmically contracting myocytes.
A Myocyte-based Flow Assist Device (MFAD) for treating a subject in need of increased flow of biological fluids, comprising:
- a vessel segment;
- and
- a sheath which comprises rhythmically contracting myocytes, the sheath disposed on at least a portion of a surface of the vessel segment,
- wherein the sheath further comprises at least one sheet of myocytes formed into a ring, and
- wherein the sheath comprises a section that comprises peacemaker-like cells while the rest of the sheath comprises ventricular-like cells.
A Myocyte-based Flow Assist Device (MFAD) for treating a subject in need of increased flow of biological fluids, comprising:
- a vessel segment;
- and
- a sheath which comprises rhythmically contracting myocytes, the sheath disposed on at least a portion of a surface of the vessel segment,
- wherein the sheath further comprises at least one sheet of myocytes formed into a ring, and
- wherein the sheath comprises a thin sheet of myocytes, having a thickness of about 50-300 microns, comprising a mixture of ventricular-like cells and pacemaker-like cells.
Dependencies are inferred from the claim text.