Biocompatible hydrogel treatments for retinal detachment
OwnerSyed H. Askari, Yeon S. Choiinventors
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Abstract
Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.
Claims22
A composition for the treatment of retinal detachment, comprising:
- (a) multi-ARM nucleophilic polyol monomers having more than two nucleophilic arms, wherein each nucleophilic arm comprises a polyethylene glycol chain and terminates in a nucleophilic group selected from a hydroxyl, thiol, and amino;
- (b) multi-ARM electrophilic polyol monomers having more than two electrophilic arms, wherein each electrophilic arm comprises a polyethylene glycol chain and terminates in an electrophilic group selected from an epoxide, maleimide, succinimidyl, and an alpha-beta unsaturated ester;
- and
- (c) sodium hyaluronate;
- wherein the viscosity of the composition is at least 4000 cP
- wherein the composition gels when placed in the eye of a subject with retinal detachment.
A composition for the treatment of retinal detachment, comprising:
- (a) multi-ARM nucleophilic polyol monomers having more than two nucleophilic arms, wherein each nucleophilic arm comprises a polyethylene glycol chain and terminates in a nucleophilic group selected from a hydroxyl, thiol, and amino;
- (b) multi-ARM electrophilic polyol monomers having more than two electrophilic arms, wherein each electrophilic arm comprises a polyethylene glycol chain and terminates in an electrophilic group selected from an epoxide, maleimide, succinimidyl, and an alpha-beta unsaturated ester;
- and
- (c) sodium hyaluronate;
- wherein the viscosity of the composition is at least 4000 cP,
- wherein the nucleophilic arms of the multi-ARM nucleophilic polyol monomers are selected from
- wherein n is 1-200.
A composition for the treatment of retinal detachment, comprising:
- (a) multi-ARM nucleophilic polyol monomers having more than two nucleophilic arms, wherein each nucleophilic arm comprises a polyethylene glycol chain and terminates in a nucleophilic group selected from a hydroxyl, thiol, and amino;
- (b) multi-ARM electrophilic polyol monomers having more than two electrophilic arms, wherein each electrophilic arm comprises a polyethylene glycol chain and terminates in an electrophilic group selected from an epoxide, maleimide, succinimidyl, and an alpha-beta unsaturated ester;
- and
- (c) sodium hyaluronate;
- wherein the viscosity of the composition is at least 4000 cP,
- wherein the electrophilic arms of the multi-ARM electrophilic polyol monomers are selected from
- wherein m is 2 or 3 and n is 1-200.
Dependencies are inferred from the claim text.