US 11,596,701 B2Granted

Disinfection method using a disinfection agent formed in situ by reaction of H2O2 and NO2-

AssigneeLeibniz-Institut FüR Plasmaforschung Und Technologie E.V.

InventorsAnsgar Schmidt-Bleker, Jörn Winter, Klaus-Dieter Weltmann, Hannes Bendt

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Abstract

The invention relates to a disinfection process comprising the feed materials H2O2 and NO2− and a mixing step and a distribution step, wherein the mixing step and the distribution step (during which each point on the surface being disinfected is wetted with a solution of active substance) are implemented during a processing period ZA. An exposure step follows, in which the distributed solution of active substance acts upon the surface in contact with the solution of active substance during an exposure period ZE. In this process, the maximum NO2− concentration during the mixing step is of 300 mM, and the time-integrated reaction rate W is represented during the exposure period ZE by the integral formula (I), where k1 denotes the pH-value-dependent speed constant of the reaction between H2O2 and NO2− and the pH value of the solution of active substance before it contacts the surface being disinfected lies in the range of 2.1≤pH≤6.8. The invention also relates to a device for providing the solution of active substance.

A disinfection method comprising contacting a surface with a peroxynitrous acid solution, the disinfection method comprising:

a mixing step at pH greater or equal to 2.1, wherein educts H2O2 and NO2− are mixed to obtain a peroxynitrous acid solution, wherein no peroxinitrate is formed in the solution;
a distribution step in which the peroxynitrous acid solution is distributed on the surface to be disinfected,
wherein the mixing step and the distribution step take place in a processing period ZA which begins at time t0 when the educts are first brought into contact with one another and ends at time t1 when each point on the surface to be disinfected is wetted with the peroxynitrous acid solution, wherein t0 is equal to 0 and t1 is greater than t0, and
subsequently an exposure step in which the distributed peroxynitrous acid solution acts on the surface contacted with the peroxynitrous acid solution over an exposure period Ze that begins at time t1 and ends after time period Ze at time t2,
wherein t2 represents the time at which each point on the surface contacted with the peroxynitrous acid solution is wetted with the peroxynitrous acid solution for a sufficient time to obtain a disinfecting effect, and wherein t2 is greater than t1,
characterized in that
the educts NO2− and H2O2 are consumed in the ratio 1:1 to form ONOOH, the maximum NO2− concentration [NO2−]0 at time to of the mixing step is 300 mM, the time-dependent concentrations of the educts [H2O2] and [NO2−] during the processing period and the exposure period are given by
[
NO
2
-
]
=
A
k
1
⁢
⁢
and
⁢
[
H
2
⁢
O
2
]
=
A
+
D
k
1
+
r
⁢
k
1
,
wherein
A
=
-
D
1
-
exp
⁡
(
D
⁡
(
t
-
C
)
)
,
C
=
-
ln
⁡
(
D
[
NO
2
-
]
0
·
k
1
+
1
)
D
,
⁢
D
=
[
H
2
⁢
O
2
]
0
·
(
k
1
+
r
⁢
k
1
)
-
[
NO
2
-
]
0
·
k
1
,
⁢
k
1
=
k
4
⁢
[
H
3
⁢
O
+
]
2
(
K
S
,
H
3
⁢
O
2
+
+
[
H
3
⁢
O
+
]
)
⁢
(
K
S
,
HNO
2
+
[
H
3
⁢
O
+
]
)
,
⁢
k
4
=
3.56
·
10
1
⁢
4
⁢
exp
⁡
(
-
E
A
R
⁢
T
)
⁢
M
-
1
⁢
s
-
1
,
⁢
K
S
,
H
⁢
N
⁢
O
2
=
5.13
×
1
⁢
0
-
4
,
⁢
K
S
,
H
3
⁢
O
2
+
=
2
×
1
⁢
0
-
2
,
[
H
3
⁢
O
+
]
=
1
⁢
0
-
p
⁢
H
,
E
A
=
70
⁢
⁢
k
⁢
⁢
J
⁢
/
⁢
mol
and [H2O2]0 is the initial H2O2 concentration at time t0 of the mixing step and
wherein r=0,11 is to be set, and
the time-integrated reaction rate W over the exposure period Ze fulfills the inequality
W
=
∫
t
1
t
2
⁢
k
1
·
[
H
2
⁢
O
2
]
·
[
NO
2
-
]
⁢
d
⁢
t
≥
10
⁢
⁢
mM
,
wherein t2 does not exceed 3 minutes, and
wherein k1 is the pH-dependent rate constant of the reaction between H2O2 and NO2−, and
wherein the pH of the peroxynitrous acid solution prior to contact with the surface to be disinfected is in the range of 2.1≤pH<6.8, and wherein pH value of the peroxynitrous acid solution is always greater than or equal to 2.1 before and during the distribution and exposure times.

297 more elements

Facts

Application

16/950,929Filed 18 Nov 2020 · continuation

Priority

WO PCT/EP2018/06322618 May 2018

Published

US 2021/0069361 A111 Mar 2021

Granted

7 Mar 2023

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61L 2/186
Liquid substances: peroxide solutions
A61L 2/14
Using physical processes: plasma, i.e. ionised gases
A61L 2/18
Using chemical substances: liquid substances
A61L 2103/00
Materials or objects being the target of disinfection or sterilisation

Abstract

Claims10