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US 11,596,700 B2Granted
Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
AssigneeUniversity of Rochester
InventorSteven A. Goldman
Life of this patent
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Abstract
The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model to identify agents suitable for treating a neurodegenerative disorder. The present application also relates to methods of treating neurodegenerative disorders and restoring normal brain interstitial potassium levels.
Claims23
A method of treating Huntington's disease in a human subject, said method comprising:
- selecting a human subject having Huntington's disease;
- providing a preparation of human cells comprising glial progenitor cells, wherein said glial progenitor cells of the preparation endogenously co-express CD44 and CD140a;
- and
- administering, to the selected subject, the provided preparation of human cells comprising glial progenitor cells at a dosage effective to treat Huntington's disease in the subject.
1 more element
A method of treating Huntington's disease in a human subject, said method comprising:
- selecting a human subject having Huntington's disease;
- providing a preparation of human cells comprising astrocyte-biased glial progenitor cells, wherein said astrocyte-biased glial progenitor cells of the preparation endogenously co-express CD44 and A2B5;
- and
- administering, to the selected subject, the provided preparation of human cells comprising astrocyte-biased glial progenitor cells at a dosage effective to treat Huntington's disease in the subject.
1 more element
Dependencies are inferred from the claim text.