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US 11,596,683 B2Granted
Engineered influenza polynucleotides, viruses, vaccines and methods of making and using the same
AssigneeDuke University
InventorsNicholas Scott Heaton, Alfred Theodore Harding, Brook Elizabeth Heaton
Life of this patent
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Abstract
Engineered Influenza polynucleotides, viruses, vaccines, and methods of making and using the same are provided. More specifically, the present inventors have developed replication competent engineered influenza viruses having, for example, a modified segment 4 and/or segment 6 that include at least one additional polynucleotide encoding a heterologous polypeptide.
Claims15
An engineered influenza virus segment 4 polynucleotide encoding a polypeptide comprising from N-terminus to C-terminus:
- a neuraminidase (NA) polypeptide, a furin site, a self-cleaving 2A polypeptide, and a first hemagglutinin (HA) polypeptide, wherein both the NA polypeptide and the first HA polypeptide that are expressed from the segment 4 polynucleotide are free of residual amino acids from the furin site and the self-cleaving 2A polypeptide.
Dependencies are inferred from the claim text.