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US 11,596,681 B2Granted
EHV insertion site UL43
OwnerAlice Mundt, Andreas Gallei +1inventors
InventorsAlice Mundt, Andreas Gallei, Kristina Rehmet
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Abstract
The present invention relates to the field of (vector) vaccines, and especially to the novel EHV insertion site UL43. The present invention further concerns related expression cassettes and vectors, which are suitable to express genes of interest, especially antigen encoding sequences. The viral vectors of the present invention are useful for producing an immunogenic composition or vaccine.
Claims13
An Equid Alphaherpesvirus (EHV) RacH vector comprising an expression cassette into UL43, wherein the expression cassette comprises
- (i) at least one exogenous antigen encoding sequence operably linked to a promoter sequence, and
- (ii) at least one upstream UL43 flanking region selected from the group consisting of:
- sequences having at least 90% sequence identity and/or homology to SEQ ID NO:19, sequences having at least 90% sequence identity to SEQ ID NO:26, and
- (iii) at least one upstream UL44 flanking region selected from the group consisting of:
- sequences having at least 90% sequence identity and/or homology to SEQ ID NO:20, sequences having at least 90% sequence identity to SEQ ID NO:27.
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