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US 11,596,680 B2Granted
Norovirus vaccine
AssigneeResilience Government Services, Inc.
InventorsRon Cobb, Michael Springer, Yawei Ni
Life of this patent
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AssigneeResilience Government Services, Inc.
InventorsRon Cobb, Michael Springer, Yawei Ni
Estimating the term…
A dry powder norovirus vaccine is provided, which comprises at least two norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against norovirus infections.
A method of immunizing a mammalian subject against a norovirus infection with a multivalent norovirus dry powder vaccine composition comprising a norovirus genogroup GI virus-like particle (VLP) antigen, a norovirus genogroup GII VLP antigen, and an anionic polysaccharide, the method comprising:
Dependencies are inferred from the claim text.