Hepatitis C virus gene sequences and methods of use therefor
AssigneesVanderbilt University, The Trustees of the University of Pennsylvania, The Johns Hopkins University
InventorsJames E. Crowe, Jr., Andrew Flyak, Justin Bailey, Stuart Ray, George Shaw
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Abstract
The present disclosure relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present disclosure provides a composition comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof.
Claims19
A vaccine composition comprising (a) at least one antigen or an immunogenic fragment thereof, and (b) a pharmaceutically acceptable carrier, diluent or excipient, and wherein:
- (i) said vaccine composition further comprises an adjuvant or immunostimulatory agent;
- or
- (ii) said vaccine composition comprises nanoparticles, coated by or containing said antigen or immunogenic fragment,
- wherein said antigen or immunogenic fragment thereof is a variant of one of SEQ ID NOs:
- 28, 29, 30, 31, 32, 33, 34, 35 or 36 and has at least about 97%, about 97.5%, about 98%, about 98.5%, about 99%, about 99.5% or about 99.9% identity to that of any one of SEQ ID NOs:
- 28, 29, 30, 31, 32, 33, 34, 35 or 36.
A vaccine composition comprising (a) at least one nucleic acid or a fragment thereof, and (b) a pharmaceutically acceptable carrier, diluent or excipient, and wherein:
- (i) said vaccine comprises a lipid, a preservative, an adjuvant and/or an immunostimulatory agent;
- or
- (ii) said vaccine composition comprises nanoparticles coated by or containing said nucleic acid,
- wherein said nucleic acid or fragment thereof is a variant of one of SEQ ID NOs:
- 19, 20, 21, 22, 23, 24, 25, 26 or 27 and has at least about 97%, about 97.5%, about 98%, about 98.5%, about 99%, about 99.5% or about 99.9% identity to that of any one of SEQ ID NOs:
- 19, 20, 21, 22, 23, 24, 25, 26 or 27.
Dependencies are inferred from the claim text.