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US 11,596,674 B2Granted
Method and compositions for inhibiting or preventing adverse effects of oral antibiotics
AssigneeSynthetic Biologies, Inc.
InventorsMichael Kaleko, Sheila Connelly, Vincent John Wacher
Life of this patent
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Abstract
This invention provides, in part, various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.
Claims19
A beta-lactamase formulation comprising at least one particle with each particle comprising:
- about 0.1-1% beta-lactamase;
- about 0.1-1% hydroxypropylmethylcellulose acetate succinate (HPMCAS);
- about 5-15% ethylcellulose dispersion;
- about 0.1-1% sodium stearyl fumarate;
- about 0.1-1% buffer;
- about 0.5-5% trehalose;
- and
- about 80-90% water.
5 more elements
A beta-lactamase formulation comprising at least one pellet with each pellet comprising:
- about 0.5% by weight beta-lactamase, the beta-lactamase comprises an amino acid sequence having at least 95% identity with the amino acid sequence selected from SEQ ID NO:
- 1 and SEQ ID NO:
- 5;
- about 0.3% hydroxypropylmethylcellulose acetate succinate (HPMCAS);
- about 10.1% ethylcellulose dispersion;
- about 0.2% sodium stearyl sodium stearyl fumarate;
- about 0.1% buffer;
- about 1.0% trehalose;
- and
- about 88.8% water.
7 more elements
Dependencies are inferred from the claim text.