Method for treating or preventing idiopathic polypoidal choroidal vasculopathy (IPCV)

A method for treating idiopathic polypoidal choroidal vasculopathy (IPCV), comprising administering to a subject in need thereof:

• (a) an anti-C5 agent and (b) a VEGF antagonist,
• wherein (a) and (b) are administered in an amount that is effective for treating IPCV,
• wherein the administering occurs for a first administration period induction phase followed by a second administration period maintenance phase wherein only the anti-C5 agent is administered monthly throughout the maintenance phase, and
• wherein the anti-C5 agent is a pegylated aptamer (avacincaptad pegol) with the following nucleotide sequence:
• fCmGfCfCGfCmGmGfUfCfUfCmAmGmGfCGfCfUmGmAmGfUfCfUmG mAmGfUfUfUAfCf CfUmGfCmG-3T (SEQ ID NO:
• 1), or a pharmaceutically acceptable salt thereof,
• wherein fC and fU=2′-fluoro nucleotides, and mG and mA=2′-OMe nucleotides and all other nucleotides are 2′-OH, and where 3T indicates an inverted deoxythymidine.