Stem cell-produced microvesicles for treating tendon pathologies
AssigneeAlbert Einstein College of Medicine
InventorHui B. Sun
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Abstract
Microvesicles produced by stem cells grown on a silk scaffold for enhancing stem cell self-renewal/proliferation and promoting tenogenesis in damaged tendons, and their use in tendon wound repair and tendinopathy treatment. Also provided are compositions containing the microvesicles and devices for obtaining them.
Claims15
A method of treating a damaged tendon in a mammalian subject comprising administering to the subject an amount of microvesicles derived from mammalian mesenchymal stem cells effective to treat a damaged tendon, wherein the mesenchymal stem cells have been cultured on a silk scaffold prior to the microvesicles being derived from the mesenchymal stem cells.
A method of enhancing tenogenesis in a damaged tendon in a mammalian subject comprising administering to the subject an amount of microvesicles derived from mammalian mesenchymal stem cells effective to enhance tenogenesis, wherein the mesenchymal stem cells have been cultured on a silk scaffold prior to the microvesicles being derived from the mesenchymal stem cells.
Dependencies are inferred from the claim text.