Human leukocyte antigen restricted gamma delta T cell receptors and methods of use thereof
AssigneeGadeta B.V.
InventorsJürgen Herbert Ernst Kuball, Guido Joris Jan Kierkels, Zsolt Sebestyen
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Abstract
Disclosed herein are compositions and methods of treating a subject with cancer. The compositions and methods utilize immunoresponsive cells to effect killing of tumor cells.
Claims9
A cell that comprises a polypeptide construct that comprises a γ-TCR polypeptide and a δ-TCR polypeptide, wherein said γ-TCR polypeptide comprises at least 90% identity to residues 19-309 of SEQ ID NO:4, wherein said δ-TCR polypeptide comprises at least 90% identity to residue 21-293 of SEQ ID NO:
- 5.
A vector comprising a nucleic acid molecule encoding a γ-TCR polypeptide, wherein said γ-TCR polypeptide comprises at least 90% identity to residues 19-309 of SEQ ID NO:
- 4, and a nucleic acid molecule encoding a δ-TCR polypeptide, wherein said δ-TCR polypeptide comprises at least 90% identity to residues 21-293 of SEQ ID NOS:
- 5.
Dependencies are inferred from the claim text.