Back to results
US 11,596,651 B2Granted
Therapeutic metal complexes and ligands and methods of making and using the same
AssigneeOregon State University
InventorsJoseph Beckman, James Hurst, John Sirois, Chris Beaudry
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compound embodiments that are useful for treating a variety of diseases, particularly neurological diseases, motor neuron diseases, copper deficiency-related diseases, and/or mitochondrial deficiencies. The compound embodiments described herein also can be used in PET methods. Also disclosed herein are embodiments of methods of making and using the compound embodiments, as well as pharmaceutical formulations comprising the disclosed compound embodiments.
Claims9
A compound, having a structure according to a formula
- wherein
- M is copper or a radioactive isotope thereof;
- R1 is aryl-(R5)n or heteroaryl-(R5)n;
- R2 is selected from aryl, aryl-(R6)n, or CH3;
- each of R5 and R6 independently is selected from alkoxy, amine, hydroxyl, nitro, halogen, C(CF3)3, or CF3;
- and wherein n is an integer ranging from 1 to 10;
- and
- each of R3 and R4 independently is selected from —N(H)(CH2)n′CH3, —N(H)(CH2)n′CF3, —N[(CH2)n′CH3]2, or —N[(CH2)n′CF3]2, wherein each n′ independently is an integer selected from 0 to 9.
5 more elements
A compound selected from
Dependencies are inferred from the claim text.