Methods and compositions for treating meibomian gland dysfunction

A method of treating meibomian gland dysfunction, comprising topically administering to the eyelid margin of a patient in need thereof twice per day a dose of a minocycline topical suspension to treat the meibomian gland dysfunction, wherein the dose provides from about 0.1 mg to about 0.3 mg or about 0.3 mg to about 0.7 mg of minocycline, and the minocycline topical suspension comprises:

• a) minocycline in a suspended form within the topical suspension;
• b) a liquid medium that dissolves less than 5% (w/w) of the minocycline at room temperature after two hours, wherein the liquid medium contains mineral oil;
• and
• c) a polymeric hydrocarbon gelling agent;
• wherein particles of minocycline in the topical suspension have a D90 particle size less than 8 microns, and the topical suspension comprises about 0.3% (w/w) minocycline.