Substituted indole Mcl-1 inhibitors

A compound having formula:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• R3 is
• R7 is
• Rb is hydrogen, hydroxy, alkyl, heteroalkyl, heterocyclyl, or heterocyclylalkyl, wherein said alkyl, heteroalkyl, heterocyclyl, and heterocyclylalkyl are independently substituted by 0, 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of halogen, oxo (═O), ═S, cyano, nitro, fluoroalkyl, alkoxyfluoroalkyl, fluoroalkoxy, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, heteroalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl, cycloalkylalkyl, cycloalkenylalkyl, heteroarylalkyl, arylalkyl, heterocyclylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkylthio, alkoxyalkyl, alkylene, aryloxy, arylthio, phenoxy, benzyloxy, amino, alkylamino, dialkylamino, acylamino, aminoalkyl, arylamino, diarylamino, sulfonylamino, sulfinylamino, sulfonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, sulfinyl, —COOH, ketone, alkoxycarbonyl, aryloxycarbonyl, amide, carbamate, acyl, boronic acid, or boronic ester;
• and
• L4-Rw is an optionally substituted 8-10 membered bicyclic saturated, partially unsaturated or aryl ring, an optionally substituted 8-10 membered bicyclic saturated or partially unsaturated heterocyclic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an optionally substituted 8-10 membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur.