US 11,596,638 B2 · 18-MC for treatment of substance use disorders

Abstract

A composition for treating substance use disorders of an effective amount of 18-Methoxycoronaridine salt (18-MC) in a pharmaceutical carrier. A method of treating substance use disorders, by administering an effective amount of 18-Methoxycoronaridine salt (18-MC) in a pharmaceutical carrier to an individual and preventing substance abuse in the individual. A method of preventing addictive behavior in an individual. A method of preventing craving in an individual. A composition of a metabolite of 18-MC salt. A method of treating substance use disorders by administering an effective amount of a metabolite of 18-MC salt in a pharmaceutical carrier to an individual and preventing substance abuse in the individual. A composition having various pharmacokinetic profiles as shown in the Figures.

Claims8

Dependent claims

A method of treating substance use disorders, including the steps of:

administering an effective amount of 18-Methoxycoronaridine salt (18-MC) in a pharmaceutical carrier to an individual, wherein the individual is a human, wherein the 18-MC administered follows a multiple-compartment model and a half-life is about 48 hours;
and
preventing treating substance abuse in the individual, wherein the substance is chosen from the group consisting of cocaine, nicotine, opiates, alcohol, morphine, and methamphetamine.

Dependencies are inferred from the claim text.

Facts

Application

17/060,443Filed 1 Oct 2020 · us provisional application

Priority

1 Oct 2019

Published

US 2021/0093643 A11 Apr 2021

Granted

7 Mar 2023

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

A61K 31/55
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 9/0053
Galenical forms characterised by the site of application: mouth and digestive tract, i.e. intraoral and peroral administration
A61P 25/30
Drugs for disorders of the nervous system: for treating abuse or dependence
A61K
Medicines and medical preparations

18-MC for treatment of substance use disorders

Life of this patent

18-MC for treatment of substance use disorders

Life of this patent

Abstract

Claims8