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US 11,596,631 B2Granted
CDK12 inhibitors and their uses
AssigneeThe University of Nottingham
InventorsChristopher James Hayes, John David Brook, Ami Ketley
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Abstract
The invention relates to inhibitors of CDK12 (cyclin-dependent kinase 12), and there use in the treatment or prevention of a disorder in a subject caused by the generation of repeat expansion transcripts.
Claims29
A method of treatment of a disorder caused by the generation of repeat expansion transcripts in a subject, comprising administering an inhibitor of CDK12 to the subject, wherein the disorder is selected from the group consisting of Myotonic Dystrophy type 1, Myotonic Dystrophy type 2, and frontotemporal dementia (C9ORF72).
Dependencies are inferred from the claim text.