Compounds and methods for treating cancer
AssigneeMayo Foundation for Medical Education and Research
InventorsJohn A. Copland, III, Christina Von Roemeling, Han W. Tun, Thomas R. Caulfield, Yon Son Kim
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Abstract
The present application provides methods and compositions for treating cancer, for example, renal cell carcinoma, melanoma, ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancer, and more particularly to using an inhibitor of a stearoyl-Coenzyme A desaturase 1 (SCD1) enzyme in combination with a checkpoint inhibitor to treat these disorders.
Claims10
A method of treating cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound of formula:
- or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of a checkpoint inhibitor selected from an antibody of cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) and an antibody of T-cell immunoglobulin and mucin-domain containing-3 (TIM-3).
Dependencies are inferred from the claim text.