Compound for use against pathogenic Neisseria and Haemophilus species and Moraxella catarrhalis
AssigneeUniversität Konstanz
InventorsThomas Böttcher, David Szamosvari, Christof Hauck, Tamara Schuhmacher, Petra Muenzner-Voight
Life of this patent
Estimating the term…
Abstract
The present invention relates to a compound, which can be used in the prevention and treatment of infections with pathogenic Neisseria species, in particular N. gonorrhoeae and N. meningitidis (the gonococcus and the meningococcus, respectively), and other pathogenic bacteria (e.g. Haemophilus species or Moraxella catarrhalis), and which can be used for disinfecting a substrate from said bacteria. Moreover, the present invention relates to a corresponding pharmaceutical composition comprising said compound.
Claims17
A method for preventing or treating infections from a pathogen selected from Neisseria species, Haemophilus species and Moraxella catarrhalis in a mammal, the method comprising administering to said mammal a composition comprising a compound represented by the general Formula (1) or a pharmaceutically acceptable salt thereof
- wherein
- R1 is selected from the group consisting of a substituted or unsubstituted alkyl group
- having from 3 to 20 carbon atoms, a substituted or unsubstituted cycloalkyl group
- having from 4 to 12 carbon atoms, a substituted or unsubstituted alkenyl group
- having from 3 to 20 carbon atoms, a substituted or unsubstituted cycloalkenyl group
- having from 4 to 12 carbon atoms, a substituted or unsubstituted alkynyl group
- having from 3 to 20 carbon atoms, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heteroaryl group;
- R7 is selected from the group consisting of a hydrogen atom, a methyl group, and —OH;
- R2 is selected from the group consisting of a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, a halogen atom, —NZ1Z2, —NO2, and —OZ3, wherein Z1 to Z3 are each independently selected from the group consisting of a hydrogen atom and a methyl group;
- X1 to X4 are each independently selected from a carbon atom and a nitrogen atom with the proviso that the respective R3 to R6 is absent, when the corresponding X1 to X4 is a nitrogen atom, and wherein at most two of X1 and X4 is/are a nitrogen atom;
- and
- R3 to R6, when present, are each independently selected from the group consisting of a hydrogen atom, a methyl group, a fluorine atom, and —OE3, wherein E3 is selected from the group consisting of a hydrogen atom, and a methyl group.
A method for disinfecting a substrate from a pathogen selected from Neisseria species, Haemophilus species and Moraxella catarrhalis, the method comprising disinfecting the substrate with a compound represented by the general Formula (1) or a pharmaceutically acceptable salt thereof
- wherein
- R1 is selected from the group consisting of a substituted or unsubstituted alkyl group
- having from 3 to 20 carbon atoms, a substituted or unsubstituted cycloalkyl group
- having from 4 to 12 carbon atoms, a substituted or unsubstituted alkenyl group
- having from 3 to 20 carbon atoms, a substituted or unsubstituted cycloalkenyl group
- having from 4 to 12 carbon atoms, a substituted or unsubstituted alkynyl group
- having from 3 to 20 carbon atoms, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heteroaryl group;
- R7 is selected from the group consisting of a hydrogen atom, a methyl group, and —OH;
- R2 is selected from the group consisting of a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, a halogen atom, —NZ1Z2, —NO2, and —OZ3, wherein Z1 to Z3 are each independently selected from the group consisting of a hydrogen atom and a methyl group;
- X1 to X4 are each independently selected from a carbon atom and a nitrogen atom with the proviso that the respective R3 to R6 is absent, when the corresponding X1 to X4 is a nitrogen atom, and wherein at most two of the X1 and X4 is/are a nitrogen atom;
- and
- R3 to R6, when present, are each independently selected from the group consisting of a hydrogen atom, a fluorine atom and —OE3, wherein E3 is selected from the group consisting of a hydrogen atom and a methyl group;
- and
- the substrate is selected from the group consisting of medical tools, medical equipment, floor, linen, paper, and medical and industrial surfaces.
A method for treating infections from a pathogen selected from Neisseria species, Haemophilus species and Moraxella catarrhalis in a mammal, the method comprising administering to said mammal a composition comprising a compound selected from the group consisting of the compounds represented by the following Formulas (2) to (7), or a pharmaceutically acceptable salt thereof:
A method for disinfecting a substrate from a pathogen selected from Neisseria species, Haemophilus species and Moraxella catarrhalis , the method comprising disinfecting the substrate with a compound selected from the group consisting of the compounds represented by the following Formulas (2) to (7), or a pharmaceutically acceptable salt thereof:
Dependencies are inferred from the claim text.