Formulations with reduced oxidation
AssigneeF. Hoffmann-La Roche AG
InventorsSreedhara Alavattam, Mary Mallaney, Parbir Grewal
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Abstract
The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.
Claims16
A liquid formulation comprising an antibody and a compound which prevents oxidation of the antibody in the liquid formulation upon storage for at least 8 hours, wherein the compound generates less reactive oxygen species in the formulation compared to tryptophan, wherein the compound is selected from the group consisting of N-acetyl-L-tryptophanamide, 5-amino-DL-tryptophan, and 5-hydroxyindole-3-acetic acid, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.