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US 11,596,615 B2Granted
Compositions and methods for treatment of insulin resistance
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsSalim Merali, Carlos A. Barrero, Wayne E. Childers, George C. Morton
Life of this patent
Estimating the term…
Abstract
Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
Claims29
A method of reducing impaired glucose tolerance in a subject in need thereof, comprising administering to the subject an effective amount of a compound according to Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from the group consisting of hydrogen, —(C1-C8)alkyl, —(C1-C8)alkenyl, —(C1-C8)alkynyl, unsubstituted or substituted -ara(C1-C6)alkyl, unsubstituted or substituted -heteroara(C1-C6)alkyl, where the substituents on said substituted ara(C1-C6)alkyl and substituted heteroara(C1-C6)alkyl are selected from the group consisting of halogen, —CN, —NO2, —NH2, —NH(C1-C6)alkyl, —N[(C1-C6)alkyl)]2, —OH, halo(C1-C6)alkyl, —(C1-C6)alkoxy, halo(C1-C6)alkoxy, —SH, thio(C1-C6)alkyl, —SONH2, —SO2NH2, —SO—(C1-C6)alkyl, —SO2—(C1-C6)alkyl, —NHSO2(C1-C6)alkyl, and —NHSO2NH2;
- R2 is selected from the group consisting of hydrogen, —(C1-C8)alkyl, —(C1-C8)alkenyl, —(C1-C8)alkynyl, unsubstituted or substituted -ara(C1-C6)alkyl, unsubstituted or substituted -heteroara(C1-C6)alkyl, where the substituents on said substituted ara(C1-C6)alkyl and substituted heteroara(C1-C6)alkyl are selected from the group consisting of halogen, —CN, —NO2, —NH2, —OH, halo(C1-C6)alkyl, —(C1-C6)alkoxy, halo(C1-C6)alkoxy, —SH, thio(C1-C6)alkyl, —SONH2, —SO2NH2, —SO—(C1-C6)alkyl, —SO2—(C1-C6)alkyl, —NHSO2(C1-C6)alkyl, and —NHSO2NH2;
- R3, R4, R7, R8, R9, R10, R13 and R14 are independently selected from the group consisting of hydrogen and —(C1-C6)alkyl;
- R5 and R6 are independently selected from the group consisting of hydrogen, —(C1-C6)alkyl and —OH, provided that both R5 and R6 cannot be —OH;
- R11 and R12 are independently selected from the group consisting of hydrogen, —(C1-C6)alkyl and —OH, provided that both R11 and R12 cannot be —OH;
- m is 1, 2, 3, or 4;
- n is 0, 1, 2, 3, or 4;
- o is 0, 1, 2, 3, or 4;
- p is 1, 2, 3, or 4;
- q is 0, 1, 2, 3, or 4;
- and
- r is 0, 1, 2, 3, or 4.
10 more elements
A method of treating or preventing diabetes in a subject in need thereof, comprising administering to the subject an effective amount of a compound according to Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from the group consisting of hydrogen, —(C1-C8)alkyl, —(C1-C8)alkenyl, —(C1-C8)alkynyl, unsubstituted or substituted -ara(C1-C6)alkyl, unsubstituted or substituted -heteroara(C1-C6)alkyl, where the substituents on said substituted ara(C1-C6)alkyl and substituted heteroara(C1-C6)alkyl are selected from the group consisting of halogen, —CN, —NO2, —NH2, —NH(C1-C6)alkyl, —N[(C1-C6)alkyl)]2, —OH, halo(C1-C6)alkyl, —(C1-C6)alkoxy, halo(C1-C6)alkoxy, —SH, thio(C1-C6)alkyl, —SONH2, —SO2NH2, —SO—(C1-C6)alkyl, —SO2—(C1-C6)alkyl, —NHSO2(C1-C6)alkyl, and —NHSO2NH2;
- R2 is selected from the group consisting of hydrogen, —(C1-C8)alkyl, —(C1-C8)alkenyl, —(C1-C8)alkynyl, unsubstituted or substituted -ara(C1-C6)alkyl, unsubstituted or substituted -heteroara(C1-C6)alkyl, where the substituents on said substituted ara(C1-C6)alkyl and substituted heteroara(C1-C6)alkyl are selected from the group consisting of halogen, —CN, —NO2, —NH2, —OH, halo(C1-C6)alkyl, —(C1-C6)alkoxy, halo(C1-C6)alkoxy, —SH, thio(C1-C6)alkyl, —SONH2, —SO2NH2, —SO—(C1-C6)alkyl, —SO2—(C1-C6)alkyl, —NHSO2(C1-C6)alkyl, and —NHSO2NH2;
- R3, R4, R7, R8, R9, R10, R13 and R14 are independently selected from the group consisting of hydrogen and —(C1-C6)alkyl;
- R5 and R6 are independently selected from the group consisting of hydrogen, —(C1-C6)alkyl and —OH, provided that both R5 and R6 cannot be —OH;
- R11 and R12 are independently selected from the group consisting of hydrogen, —(C1-C6)alkyl and —OH, provided that both R11 and R12 cannot be —OH;
- m is 1, 2, 3, or 4;
- n is 0, 1, 2, 3, or 4;
- o is 0, 1, 2, 3, or 4;
- p is 1, 2, 3, or 4;
- q is 0, 1, 2, 3, or 4;
- and
- r is 0, 1, 2, 3, or 4.
10 more elements
Dependencies are inferred from the claim text.