Compositions and methods for treating cancer
AssigneeUniversity of Iowa Research Foundation
InventorsMichael K. Schultz, Somya Kapoor, Douglas R. Spitz
Life of this patent
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Abstract
The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition.
Claims11
A combination of buthionine sulfoximine (BSO) and an anti-cancer composition comprising dabrafenib and cobimetinib for the therapeutic treatment of a drug-resistant melanoma, said BSO administered in a dose of from 1.5-17 g/m2.
A kit comprising buthionine sulfoximine (BSO), a container, and a package insert or label indicating the administration of the BSO with an anti-cancer composition comprising dabrafenib and cobimetinib for treating a drug-resistant melanoma, said BSO administered in a dose of from 1.5-17 g/m2.
A method for treating a drug-resistant melanoma in a mammal, comprising administering to the mammal that is resistant to MAPK pathway inhibitor and/or could acquire resistance to MAPK pathway inhibitors a combination of buthionine sulfoximine (BSO) and an anti-cancer composition comprising dabrafenib and cobimetinib, said BSO administered in a dosage of from 1.5-17 g/m2.
Dependencies are inferred from the claim text.