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US 11,596,601 B2Granted
Mucoadhesive gel composition
AssigneeViramal Limited
InventorsWilliam Bologna, François Boutignon, Lea Louvel, Finn Larsen, Simona Fiore, Oliver Bates
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Abstract
A pharmaceutical mucoadhesive gel composition for delivering therapeutic agents (such as progesterone) by buccal, nasal, vaginal and rectal administration, thereby avoiding the hepatic first-pass metabolism. The gel composition comprises a vehicle with a gel-forming agent and a bioadhesive agent; and a therapeutic agent dispersed or suspended in the vehicle.
Claims19
A stable pharmaceutical mucoadhesive gel composition, comprising:
- a) a vehicle comprising:
- (i) a gel-forming agent, wherein the gel-forming agent constitutes 0.5% up to 30% by weight of the stable pharmaceutical mucoadhesive gel composition;
- (ii) a bioadhesive agent, wherein the bioadhesive agent constitutes 0.5% up to 40% by weight of the stable pharmaceutical mucoadhesive gel composition;
- and
- (iii) an oil composition, wherein the oil composition comprises a mixture of liquid paraffin and petrolatum;
- and
- b) micronized progesterone, wherein the micronized progesterone is present in an amount of 1% up to 20% by weight of the stable pharmaceutical mucoadhesive gel composition,
- wherein the stable pharmaceutical mucoadhesive gel composition has a viscosity in the range of about 139.5 Pascal seconds (Pa·s) up to about 418.5 Pa·s at about 21 degrees Celsius.
5 more elements
Dependencies are inferred from the claim text.