Chlorogenic acid-containing composition for nasal administration
AssigneeSichuan Jiuzhang Biological Science and Technology Co., Ltd.
InventorsJie Zhang, Wang Huang, Fei Zhang, Ya Zhang
Life of this patent
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Abstract
An anti-tumor composition for nasal administration has chlorogenic acid as an active ingredient, with the addition of pharmaceutically acceptable excipients or auxiliary ingredients. The chlorogenic acid preparation can improve the bioavailability of chlorogenic acid for nasal administration, penetrate the blood-brain barrier, have a significant inhibitory effect on brain tumors and nasopharyngeal carcinoma, and possess a clinical application value.
Claims9
An anti-tumor composition for nasal administration that is a preparation comprising chlorogenic acid as an active ingredient and pharmaceutically acceptable excipients or auxiliary ingredients suitable for nasal administration,
- wherein:
- said preparation is nasal powder;
- the excipients of said nasal powder are adhesive and absorption enhancer;
- said nasal powder comprises 10-90 parts of chlorogenic acid, 5-80 parts of the adhesive, and 0-70 parts of the absorption enhancer;
- the adhesive is selected from one or more of carbomer, chitosan, and polyvinylpyrrolidone;
- and
- the absorption enhancer is selected from one or more of lecithin and cholic acid sodium.
An anti-tumor composition for nasal administration that is a preparation comprising chlorogenic acid as an active ingredient and pharmaceutically acceptable excipients or auxiliary ingredients suitable for nasal administration, wherein:
- said preparation is aerosol containing 0.1-1 g chlorogenic acid per 1 mL;
- the excipients of said aerosol are propellant, cosolvent and absorption enhancer;
- the excipients comprises 5-30 parts by weight of the propellant, 10-50 parts of the cosolvent, and 1-10 parts of the absorption enhancer;
- the propellant is selected from any one or more of dichlorodifluoromethane and trichlorofluoromethane;
- the cosolvent is selected from any one or more of ethanol, glycerin, and propylene glycol;
- and
- the absorption enhancer is selected from any one or more of azone, sodium ethylenediaminetetraacetate, and oleic acid.
Dependencies are inferred from the claim text.