Hyaluronic acid filler using microneedle patch

A soluble microneedle for delivering filler particles into skin comprising:

• (i) a material forming a soluble microneedle comprising a mixture of oligo hyaluronic acid, sodium carboxymethyl cellulose (Na-CMC) and a plasticizer;
• and
• (ii) a plurality of filler particles comprising crosslinked hyaluronic acid and trehalose,
• wherein the molecular weight of the crosslinked hyaluronic acid is 100,000 to 5,000,000, and is comprised in an amount of 0.01 to 40% by weight based on the total weight of the microneedle,
• wherein the trehalose is comprised in an amount of 0.05 to 10% by weight based on the total weight of the plurality of filler particles,
• wherein the trehalose and the crosslinked hyaluronic acid are comprised at a weight ratio of 1:0.0001 to 0.1 (trehalose:crosslinked hyaluronic acid),
• wherein the soluble microneedle is formed from a microneedle solution consisting of the oligo hyaluronic acid, the Na-CMC, the plasticizer, the crosslinked hyaluronic acid, the trehalose, and water,
• wherein the filler particles are impregnated in the material forming the soluble microneedle;
• wherein the filler particles are adapted to be delivered when the material forming a soluble microneedle dissolves after the microneedle is applied into skin;
• and
• wherein the crosslinked hyaluronic acid in the filler particles are adapted to be swelled after intradermal or subcutaneous delivery of the filler particles.