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US 11,596,584 B2Granted
Skin treatment methods and compositions for transdermal delivery of active agents
AssigneeTopix Pharmaceuticals, Inc.
InventorSteven M. Hernandez
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Abstract
Disclosed are stable, non-irritating, skin treatment active agents containing formulations and delivery systems for topical application to the skin. The disclosed topical formulations and delivery systems provide controlled, gentle release of the active agents into the skin for the treatment of amenable skin conditions as well as for improvement of aesthetic skin properties. Also provided are methods for the formulation, manufacture and use of the disclosed formulations and delivery systems.
Claims7
A topical formulation comprising:
- a skin treatment active agent comprising about 0.01% to about 30% retinol;
- an activation solvent system comprising about 10% to about 90% isopentyldiol, about 5% to about 90% dimethyl isosorbide, and a non-ionic surfactant, wherein the formulation comprises (% w/w):
- about 1% to about 40% polysorbate 80;
- about 0.01% to about 10% caffeine;
- up to about 80% ethoxydiglycol;
- about 0.1% to about 15% green tea polyphenols isolated and purified from the leaves of Camellia sinensis plants;
- up to about 30% polysorbate 20;
- up to about 20% bakuchiol;
- up to about 20% black tea extract;
- and
- up to about 20% licorice root extract wherein the ethoxydiglycol, polysorbate 20, bakuchiol, black tea extract, and licorice root extract are present in the formulation.
8 more elements
Dependencies are inferred from the claim text.