Systems and methods for ocular drug delivery

An apparatus, comprising:

• a housing having a distal end portion configured to contact a surface of an eye, the housing defining a reservoir configured to contain a medicament having an ionic charge, the reservoir having walls with a charge opposite a charge of the medicament such that the reservoir is configured to hold the medicament in the reservoir;
• a puncture member defining a lumen, the puncture member fluidically coupled to the reservoir and configured to deliver the medicament to a target region within the eye;
• an electrode operably coupled to the medicament disposed within the reservoir, the electrode configured to produce a charge sufficient to convey the medicament from the reservoir to a distal end of the puncture member within the target region within the eye through the lumen below an outer portion of the eye;
• a controller configured to send a signal to the electrode to adjust the charge such that the medicament is conveyed from the reservoir;
• and
• a sensor, the sensor configured to detect at least one of the charge of the electrode, a level of the medicament within the reservoir, or an indication of delivery depth of the medicament.

An apparatus, comprising:

• a housing having a distal end portion configured to contact a surface of an eye, the housing defining a reservoir configured to contain a medicament having an ionic charge, the reservoir having walls with a charge opposite a charge of the medicament such that the reservoir is configured to hold the medicament in the reservoir;
• a puncture member defining a lumen, the puncture member fluidically coupled to the reservoir and configured to deliver the medicament to a target region within the eye;
• an electrode coupled to the medicament disposed within the reservoir, the electrode configured to produce a charge sufficient to convey the medicament from the reservoir to a distal end of the puncture member at a delivery depth within a predetermined range in the eye, the delivery depth dependent on an intensity of the charge;
• a controller configured to adjust the charge to convey the medicament to the predetermined delivery depth;
• and
• a sensor, the sensor configured to detect at least one of a position of the distal end portion of the housing, a level of the medicament within the reservoir, or an indication of delivery depth of the medicament.

An apparatus, comprising:

• a housing having a distal end portion configured to contact a surface of an eye, the housing defining a reservoir configured to contain a medicament having an ionic charge, the reservoir having walls with a charge opposite a charge of the medicament such that the reservoir is configured to hold the medicament in the reservoir;
• the reservoir having walls with a charge opposite a charge of the medicament such that the reservoir is configured to hold the medicament in the reservoir;
• a puncture member defining a lumen, the puncture member fluidically coupled to the reservoir and configured to deliver the medicament to a target region within the eye;
• and
• an electrode operably coupled to the medicament disposed within the reservoir, the electrode configured to produce a charge sufficient to convey the medicament from the reservoir to a distal end of the puncture member at a delivery depth within a predetermined range in the eye, the delivery depth dependent on an intensity of the charge,
• wherein the distal end portion of the housing defines a channel in fluid communication with the reservoir, inner walls of the channel define an opening through which the medicament can be conveyed to a targeted region, the apparatus further comprising:
• a membrane covering the opening and having an ionic charge such that when the ionic charge of the membrane is similar to the ionic charge of the medicament, the membrane limits the medicament from passing therethrough, and when the ionic charge of the membrane is different from the ionic charge of the medicament, the medicament can pass therethrough,
• the electrode configured to produce the ionic charge of the membrane.

An apparatus, comprising:

• a housing having a distal end portion configured to contact a surface of an eye, the housing defining a reservoir configured to contain a medicament having an ionic charge;
• an electrode coupled to the housing, the electrode configured to produce a charge sufficient to convey the medicament from the reservoir to a delivery depth within a predetermined range in the eye, the delivery depth dependent on an intensity of the charge;
• and a controller configured to adjust the charge to convey the medicament to the medicament delivery depth within the predetermined range;
• a puncture member defining a pathway, the puncture member fluidically coupleable to the reservoir and configured to deliver the medicament to a targeted region within the eye;
• and
• a contact member fixedly coupled to the housing, the contact member configured to move relative to the housing from a vertical orientation to a horizontal orientation to move an outer portion of the eye to define a pathway through which a distal end portion of the puncture member can be disposed,
• the distal end portion of the housing defining a channel in fluid communication with the reservoir, inner walls of the channel defining an opening through which the medicament can be conveyed to the targeted region;
• and
• a membrane covering the opening and having an ionic charge such that when the ionic charge of the membrane is similar to the ionic charge of the medicament, the membrane limits the medicament from passing therethrough, and when the ionic charge of the membrane is different from the ionic charge of the medicament, the medicament can pass therethrough,
• the electrode configured to produce the ionic charge of the membrane.