Modified demineralized cortical bone fibers
AssigneeMusculoskeletal Transplant Foundation
InventorsMichele McAllister, David Wang, Michelle Bubear, Joed Canales, Amy Chang, Roman Shikhanovich, Mark Spilker, Eric Semler
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Abstract
Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.
Claims16
A method for producing an implant from modified demineralized cortical bone fibers, said method comprising the steps of:
- contacting the demineralized cortical bone fibers with a salt solution prior to lyophilizing;
- and
- shaping a mass of demineralized cortical bone fibers to form an implant having a desired shape;
- and
- lyophilizing the implant to produce a lyophilized implant that has a residual moisture content of less than about 6% by weight, based on the total weight of the implant, and a complete rehydration time of less than about 30 minutes, and wherein said lyophilized implant remains cohesive and retains its shape upon complete hydration.
A method for producing an implant from modified demineralized cortical bone fibers, said method comprising the steps of:
- contacting the demineralized cortical bone fibers with a salt solution prior to lyophilizing;
- shaping a mass of demineralized cortical bone fibers to form an implant having a desired shape;
- curing the implant at a temperature of from about 20° C. to about 50° C. for a period of up to about 48 hours by one or more techniques selected from air drying, heat drying and applying energy to the implant, said curing step being performed prior to said lyophilizing step;
- and
- lyophilizing the implant to produce a lyophilized implant that has a residual moisture content of less than about 6% by weight, based on the total weight of the implant, and a complete rehydration time of less than about 30 minutes, and wherein said lyophilized implant remains cohesive and retains its shape upon complete hydration.
Dependencies are inferred from the claim text.