Detection of hypokinetic and hyperkinetic states

An automated method of determining a bradykinetic state of a person with Parkinson's disease, the method comprising:

• receiving a time series of motion data obtained from a motion detector worn on an extremity of the person over an extended period during non-clinically prompted activities of the person;
• applying, by a processor, a band pass filter to the motion data to extract filtered data for a band of interest, wherein the band of interest has a lower end cut off frequency of 0.05 Hz and an upper end cut off frequency of 15 Hz;
• identifying, by the processor, one or more movements of peak acceleration in the filtered data by:
• extracting a plurality of bins of motion data from the filtered data;
• and
• for each of the plurality of extracted bins of filtered data, identifying a maximum acceleration value, wherein for that extracted bin of filtered data, the maximum acceleration value represents a movement of peak acceleration of the one or more movements of peak acceleration;
• and
• from the identified one or more movements of peak acceleration, determining, by the processor, a measure of bradykinetic state;
• identifying bradykinetic motions by:
• (i) calculating, by the processor, spectral content of a sub-bin of motion data centered on each of the movements of peak acceleration, and
• (ii) determining, by the processor, bradykinetic motions to exist when there is a plurality of low frequency components of less than 4 Hz in the spectral content;
• and
• responsive to the processor determining the measure of bradykinetic state, displaying, by a display device, a visible output representing an objective assessment of the bradykinetic symptoms of Parkinson's disease experienced by the person, wherein at least one of an amount of medication in a dose and a timing of the dose of medication is caused to be altered responsive to the displayed visible output being outside a range for a designated period of time.