Methods for sub-typing and treating cancer
AssigneeHi-Stem Ggmbh
InventorsAndreas Trumpp, Simon Raffel, Mattia Falcone
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Abstract
This invention relates to a novel approach for the identification and stratification of subtypes of cancer, particularly subtypes of cancer characterized by an increased expression of BCAT1, particularly Acute Myeloid Leukemia (AML). The invention furthermore relates to a novel approach with respect to the treatment of cancer, particularly subtypes of cancer characterized by an increased expression of BCAT1, particularly Acute Myeloid Leukemia (AML).
Claims7
A method of treating Acute Myeloid Leukemia (AML) in a patient suffering from AML, wherein said AML is characterized by BCAT1high expression and IDHwtTETwt, comprising the step of administering a compound that increases intracellular levels of α-ketoglutarate, wherein the compound is (i) a BCAT1 inhibitor selected from:
- an antisense molecule, wherein said antisense molecule consists of a nucleotide sequence from 12 to 25 nucleotides, wherein the sequence corresponds to the antisense strand of the nucleic acid sequence coding for BCAT1, an siRNA molecule, wherein said siRNA molecule has between 20 and 25 based pairs being complementary to the mRNA coding for BCAT1, and a small molecule inhibitor selected from 1-(aminomethyl) cyclohexaneacetic acid, compound 2 and compound 8
- or (ii) wherein said compound is selected from α-ketoglutaric acid, a mono- or dibasic salt of α-ketoglutaric acid, or a derivative of α-ketoglutaric acid having at least one of its carboxylic acid groups derivatized as ester or amide.
Dependencies are inferred from the claim text.