Apoptotic upregulation by myxoma virus expressing walleye dermal sarcoma virus orfC
AssigneeColorado State University Research Foundation
InventorsAmy MacNeill, Sandra Quackenbush, Laura Ashton
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Abstract
A recombinant myxoma virus that encodes the orfC gene of walleye dermal sarcoma virus (WDSV). The orfC gene of walleye dermal sarcoma virus (WDSV) plays a role in induction of seasonal regression of tumors caused by WDSV. This gene was isolated from WDSV and recombined into myxoma virus (MYXV orfC) for use as an oncolytic therapy. The recombinant myxoma virus can be used in oncolytic virus therapy to specifically target and lyse cancer cells without harming healthy cells in cancer patients.
Claims8
A recombinant myxoma virus that encodes the orfC gene of walleye dermal sarcoma virus (WDSV).
Dependencies are inferred from the claim text.