Retroviral and lentiviral vectors
AssigneeAutolus Limited
InventorsVijay Peddareddigari, Richard Beswick, John Short, Martin Pulé, Ekaterini Kotsopoulou
Life of this patent
Estimating the term…
Abstract
The present invention provides a retroviral or lentiviral vector having a viral envelope which comprises a mitogenic T-cell activating transmembrane protein which comprises: (i) a mitogenic domain which binds a mitogenic tetraspanin, and (ii) a transmembrane domain; wherein the mitogenic T-cell activating transmembrane protein is not part of a viral envelope glycoprotein. When cells such as T-cells or Natural Killer cells are transduced by such a viral vector, they are activated by the mitogenic T-cell activating transmembrane protein.
Claims7
A retroviral or a lentiviral vector having a viral envelope which comprises a first mitogenic T-cell activating transmembrane protein which comprises:
- (i) a mitogenic domain which binds CD81, and
- (ii) a transmembrane domain;
- and a second mitogenic T-cell activating transmembrane protein which comprises:
- (i) a mitogenic domain which binds CD3, and
- (ii) a transmembrane domain;
- wherein the first and the second mitogenic T-cell activating transmembrane proteins are not part of the viral envelope glycoprotein.
Dependencies are inferred from the claim text.