Ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods
AssigneeNevro Corporation
InventorsDongchul Lee, Kerry Bradley, Kwan Yeop Lee
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Abstract
Systems and methods for treating a patient's pain using ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods are disclosed. A representative method for treating a patient includes positioning an implantable signal delivery device proximate to a target location at or near the patient's spinal cord, and delivering an electrical therapy signal to the target location via the implantable signal delivery device, wherein the electrical therapy signal has a frequency in a frequency range of from about 1 kHz to about 100 kHz, and wherein the frequency is increased or decreased from a first value to a second value during delivery.
Claims25
A method for treating a patient's pain, comprising delivering an electrical therapy signal to a target location via a signal delivery device;
- wherein
- the electrical therapy signal has multiple pulses at a frequency in a frequency range of from 1.2 kHz to 100 kHz,
- an amplitude of an individual pulse of the multiple pulses is ramped in only a single direction from a first value to a second value over the individual pulse's duration,
- the individual pulse is at a single polarity over the individual pulse's duration, and
- the electrical therapy signal preferentially activates inhibitory interneurons.
A method for alleviating a patient's pain, comprising:
- programming a signal generator to generate and deliver an electrical therapy signal to a target location, via at least one implanted electrode electrically coupled to the signal generator, to alleviate the patient's pain;
- wherein
- the electrical therapy signal has multiple pulses at a frequency in a frequency range of from 1.2 kHz to 100 kHz,
- the signal generator is programmed to ramp an amplitude of an individual pulse of the multiple pulses in only a single direction from a first value to a second value over the individual pulse's duration, the individual pulse being at a single polarity over the individual pulse's duration, and
- the electrical therapy signal preferentially activates inhibitory interneurons.
A system for alleviating a patient's pain, comprising:
- a signal delivery device carrying at least one electrode, the at least one electrode being positionable at or near a target location within the patient;
- and
- a signal generator coupleable to the at least one electrode and programmed to:
- generate an electrical therapy signal having multiple pulses at a frequency in a frequency range of from 1.2 kHz to 100 kHz,
- ramp an amplitude of an individual pulse of the multiple pulses in only a single direction from a first value to a second value over the individual pulse's duration, wherein the individual pulse is at a single polarity over the individual pulse's duration, and
- deliver the electrical therapy signal having the ramped amplitude to the target location via the at least one electrode to preferentially activate inhibitory interneurons and alleviate the patient's pain.
A method for treating a patient's pain, comprising:
- programming a signal delivery device to deliver an electrical therapy signal to a target location, wherein
- the electrical therapy signal includes multiple pulses at a frequency in a frequency range of from 1.2 kHz to 100 kHz,
- an amplitude of an individual pulse of the multiple pulses is ramped in only a single direction from a first value to a second value over the individual pulse's duration, and
- the individual pulse is at a single polarity over the individual pulse's duration.
Dependencies are inferred from the claim text.