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US 11,590,345 B2Granted
Treatment of tissue by the application of energy
AssigneePulse Biosciences, Inc.
InventorsDavid J. Danitz, Cameron D. Hinman, Edward Ebbers, Richard L. Nuccitelli, Kevin L. Moss, Darrin R. Uecker
Life of this patent
Estimating the term…
Abstract
Methods and apparatuses for treating a tissue with an electric treatment by rotating a pattern of electrodes partway through a treatment is disclosed. Also described herein are methods and apparatuses to treat tissue, including treating skin disorders, by selectively de-nucleating epidermal cells without provoking a significant inflammatory response, e.g., without increasing the density of leukocytes in the treated skin, and without affecting the non-cellular components of the dermis.
Claims34
A system comprising:
- a pulse generator;
- an applicator tip having a plurality of electrodes in a pattern of electrodes, wherein the applicator tip is configured to be removably coupled to a handpiece and to apply energy from the pulse generator to the plurality of electrodes and wherein the pattern of electrodes is configured to rotate about a midline through a center of the pattern of electrodes and relative to the handpiece to which the applicator tip is coupled;
- and
- a controller configured to control, at least partially, operation of the pulse generator to:
- apply a first portion of a pulsed electrical treatment to a region of tissue through the plurality of electrodes with the pattern of electrodes contacting the region in a first orientation, and
- apply a second portion of the pulsed electrical treatment to the region with the pattern in a second orientation that is rotated relative to the first orientation.
3 more elements
A system comprising:
- a pulse generator;
- an applicator tip having a plurality of electrodes in a pattern of electrodes, the applicator tip is configured to apply energy from the pulse generator to the plurality of electrodes, wherein the plurality of electrodes includes a subset of stationary needle electrodes and a subset of movable needle electrodes disposed between the stationary needle electrodes and configured to retract and extend relative to an end of the applicator tip;
- and
- a controller configured to control, at least partially, operation of the pulse generator to:
- apply a first portion of a pulsed electrical treatment to a region of tissue through the plurality of electrodes with the pattern of electrodes contacting the region in a first orientation, and
- apply a second portion of the pulsed electrical treatment to the region with the pattern in a second orientation that is rotated relative to the first orientation,
- wherein the pattern of electrodes is configured to rotate relative to the handpiece to which the applicator tip is coupled by retracting or extending the subset of movable needle electrodes.
4 more elements
A system comprising:
- a pulse generator;
- an applicator tip having a plurality of electrodes in a pattern of electrodes, wherein the applicator tip is configured to be removably coupled to a handpiece and to apply energy from the pulse generator to the plurality of electrodes and wherein the pattern of electrodes is configured to rotate relative to the handpiece to which the applicator tip is coupled;
- and
- a controller configured to control, at least partially, operation of the pulse generator to:
- apply a first portion of a pulsed electrical treatment to a region of tissue through the plurality of electrodes with the pattern of electrodes contacting the region in a first orientation, and
- apply a second portion of the pulsed electrical treatment to the region with the pattern in a second orientation that is rotated relative to the first orientation,
- wherein the applicator tip is configured to remain in the same position relative to the tissue while a first sub-set of electrodes delivers the first portion of a pulsed electrical treatment and while a second sub-set of electrodes delivers the second portion of the pulsed electrical treatment.
4 more elements
A system comprising:
- a pulse generator;
- an applicator tip having a plurality of electrodes in a pattern of electrodes, wherein the applicator tip is configured to be removably coupled to a handpiece and to apply energy from the pulse generator to the plurality of electrodes and wherein the pattern of electrodes is configured to rotate relative to the handpiece to which the applicator tip is coupled;
- and
- a controller configured to control, at least partially, operation of the pulse generator to:
- apply a first portion of a pulsed electrical treatment to a region of tissue through the plurality of electrodes with the pattern of electrodes contacting the region in a first orientation, and
- apply a second portion of the pulsed electrical treatment to the region with the pattern in a second orientation that is rotated relative to the first orientation,
- wherein the second portion of the pulsed electrical treatment is applied through different electrodes of the plurality of electrodes than the first portion of the pulsed electrical treatment is applied through.
4 more elements
Dependencies are inferred from the claim text.