Devices and methods for advancing a wire

A system for advancing a crossing wire through a vessel wall comprising:

• a first catheter comprising a catheter body having a first lumen therethrough and a first side aperture, a first deflection surface, a first alignment element and a second alignment element positioned on either side of the first side aperture within the first lumen, wherein the first deflection surface is positioned between the first alignment element and the second alignment element;
• a second catheter comprising a catheter body having a second lumen therethrough and a second side aperture, a second deflection surface, and a third alignment element and a fourth alignment element positioned on either side of the second aperture within the second lumen;
• and
• a crossing wire,
• wherein the first, second, third, and fourth alignment elements are configured to align the first and second side apertures to create a crossing wire pathway through the first and second catheters, wherein the second catheter further comprises a guide funnel positioned directly adjacent the second deflection surface and between the second deflection surface and the second lumen and configured to direct a distal tip of the crossing wire into the second lumen.