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US 11,590,263 B2Granted
Osteoinductive calcium phosphates
AssigneeNuVasive Netherlands B.V.
InventorsHuipin Yuan, Joost Dick de Bruijn
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Abstract
The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 μm, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 μm, and having a surface area percentage of micropores in a range of 10-40%.
Claims20
A porous calcium phosphate material for osteoinduction, the porous calcium phosphate material comprising:
- a plurality of grains arranged in a continuous matrix, each grain in the plurality of grains having a grain size in a range of 0.1-1.5 μm;
- and
- a plurality of micropores configured to provide spaces between grains in the plurality of grains, each micropore having a size in a range of 0.1-1.5 μm, wherein the porous calcium phosphate material is free of macropores having a size in a range of 0.1 to 1.5 mm,
- wherein a surface area percentage of the micropores is in a range from 10% to 40% over a surface of the calcium phosphate material,
- wherein the porous calcium phosphate material is configured to be resorbed at least partly after implantation, and to produce autologous bone at both an osseous site and a non-osseous site of living tissues, and
- wherein the porous calcium phosphate material has a protein adsorption capacity of at least 40%, wherein the protein adsorption capacity is expressed as a percentage of protein absorbed by a volume of 1 ml of the porous calcium phosphate material from a volume of 3 ml of a 1% aqueous solution of fetal bovine serum solution in the presence of 25 ppm sodium azide (NaN3) after 24 hours.
3 more elements
A calcium phosphate material comprising:
- a plurality of grains arranged in a continuous matrix;
- a plurality of micropores configured to provide spaces between grains in the plurality of grains, each micropore in the plurality of micropores having a size in a range of 0.1-1.5 pm,
- wherein a surface area percentage of the micropores is in a range from 10% to 40% over a surface of the calcium phosphate material;
- and
- a protein adsorption capacity of at least 40%, the protein adsorption capacity expressed as a percentage of protein absorbed by a volume of 1 ml of the calcium phosphate material from a volume of 3 ml of a 1% aqueous solution of fetal bovine serum solution in the presence of 25 ppm sodium azide (NaN3) after 24 hours.
2 more elements
Dependencies are inferred from the claim text.