Surgical repair graft
AssigneeTELA Bio, Inc.
InventorE. Skott Greenhalgh
Life of this patent
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Abstract
The apparatuses and methods described herein relates generally to the field of active agent (drug) release from surgical grafts useful for soft tissue reconstruction, regeneration, or repair. More particularly, described herein are surgical grafts for soft tissue repair that include active agent that is released over time while advantageously matching the biomechanical properties of tissue during healing and recovery.
Claims26
A surgical repair graft comprising:
- a plurality of stacked biotextile layers;
- and
- a bioabsorbable carrier matrix comprising multivesicular liposomes attached to at least one of the biotextile layers, wherein the multivesicular liposomes comprise a plurality of particles each having a plurality of non-concentric internally aqueous chambers each surrounded by a lipid membrane, at least one of the chambers and the lipid membrane containing an active agent, and wherein a first set of the chambers are on an exterior of the particles and a second set of chambers are on an interior of the particles, wherein lipid membranes on the first set of the chambers are configured to degrade before the lipid membranes on the second set of the chambers.
A surgical repair graft comprising:
- a plurality of stacked biotextile layers, wherein at least one biotextile layer comprises collagen;
- and
- a bioabsorbable carrier matrix comprising multivesicular liposomes attached to at least one of the biotextile layers, wherein the multivesicular liposomes comprise a plurality of particles each having a plurality of non-concentric internally aqueous chambers each surrounded by a lipid membrane, at least one of the aqueous chambers and the lipid membrane containing an active agent, and wherein a first set of the chambers are on an exterior of the particles and a second set of chambers are on an interior of the particles, wherein lipid membranes on the first set of the chambers are configured to degrade before the lipid membranes on the second set of the chambers.
A method for repairing an internal structure by the controlled release of an active agent from an implanted surgical repair graft, the method comprising:
- exposing a surgical repair graft having one biotextile layer or a plurality of stacked biotextile layers and a bioabsorbable carrier matrix attached to at least one of the one or plurality of stacked biotextile layers to an aqueous fluid, the carrier matrix comprising multivesicular liposomes, wherein the multivesicular liposomes comprise a plurality of particles each having a plurality of non-concentric internally aqueous chambers each surrounded by a lipid membrane, at least one of the chambers and the lipid membrane containing the active agent, wherein a first set of the chambers are on an exterior of the particles and a second set of chambers are on an interior of the particles;
- and
- degrading the carrier matrix over time by the aqueous fluid to thereby release the active agent from the carrier matrix, wherein lipid membranes on the first set of the chambers are degraded before the lipid membranes on the second set of the chambers.
Dependencies are inferred from the claim text.