Vitamin C-containing polycaprolactone microsphere filler and preparation method therefor

A method for preparing a vitamin C-containing polycaprolactone microsphere, comprising the steps of:

• (a) preparing a dispersed phase by dissolving polycaprolactone in a first solvent and dissolving vitamin C in a second solvent to prepare each solution, and then uniformly mixing the two solutions to prepare a single solution;
• (b) preparing an emulsion by mixing the dispersed phase with an aqueous solution (continuous phase) containing a surfactant;
• (c) forming a microsphere by extracting and evaporating the organic solvent from the dispersed phase into a continuous phase in the emulsion prepared in step (b);
• and
• (d) recovering the microsphere from the continuous phase of step (c) to prepare a polycaprolactone microsphere,
• wherein the polycaprolactone has an intrinsic viscosity of 0.16 to 1.90 dL/g, measured in chloroform at 25° C. using a Ubbelohde viscometer;
• the vitamin C is encapsulated in said polycaprolactone microsphere;
• and
• the microsphere has a span value of 1.0 or less.

A polycaprolactone microsphere filler comprising 2 to 50% by weight of a vitamin C-containing polycaprolactone microsphere which comprises 0.01 to 6.5% by weight of the vitamin C based on the total weight of the microsphere and has an average particle size of 10 to 100 μm;

• 0.1 to 5% by weight of a solute;
• 0 to 48% by weight of a lubricant;
• and 15 to 97.9% by weight of a pharmaceutically acceptable aqueous carrier, based on total 100% by weight of the polycaprolactone microsphere filler,
• wherein the polycaprolactone has an intrinsic viscosity of 0.16 to 1.90 dL/g, measured in chloroform at 25° C. using a Ubbelohde viscometer;
• the vitamin C is encapsulated in said polycaprolactone microsphere;
• and
• the microsphere has a span value of 1.0 or less.