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US 11,590,246 B2Granted
Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process
AssigneeGuerbet
InventorsSoizic Le Greneur, Alain Chénedé, Martine Cerf, Myriam Petta, Emmanuelle Marais, Bruno François, Caroline Robic, Stéphanie Louguet
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Abstract
The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.
Claims20
A composition comprising:
- 1) A complex of formula (II) below:
- having a diastereoisomeric excess of at least 80% of a mixture of isomers II-RRR and II-SSS of formulae:
- and
- and
- 2) A free macrocyclic ligand,
- wherein the composition has a concentration of free gadolinium of less than 1 ppm (m/v), and
- wherein the composition comprises from 0.002 to 0.4 mol/mol % of free macrocyclic ligand relative to the complex of formula (II).
4 more elements
A composition comprising:
- 1) A complex of formula (II) below:
- having a diastereoisomeric excess of at least 90% of a mixture of isomers II-RRR and II-SSS of formulae:
- and
- and
- 2) A free macrocyclic ligand being DOTA,
- wherein the composition has a concentration of free gadolinium of less than 1 ppm (m/v), and
- wherein the composition comprises from 0.002 to 0.4 mol/mol % of DOTA relative to the complex of formula (II).
4 more elements
Dependencies are inferred from the claim text.