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US 11,590,235 B2Granted
Factor VIII zwitterionic polymer conjugates
AssigneeKodiak Sciences Inc.
InventorsStephen A. Charles, Daniel Victor Perlroth, Li Song, Martin Linsell, Wayne To, Didier Benoit, James Aggen
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Abstract
The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
Claims15
A compound having the following formula:
- wherein X is an integer from 1 to 50 and Y is an integer from 1 to 50;
- and wherein Z is polymer, the polymer is synthesized with a monomer selected from the group consisting of:
- wherein R7 is H or C1-6 alkyl, ZW is a zwitterion, and t is 1 to 6.
A compound selected from the group consisting of:
- and
- wherein Z is polymer, the polymer is synthesized with a monomer selected from the group consisting of:
- wherein R7 is H or C1-6 alkyl, ZW is a zwitterion, and t is 1 to 6.
Dependencies are inferred from the claim text.