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US 11,590,233 B2Granted
Porphyrin compounds and compositions useful for treating cancer
AssigneeOncoselect Therapeutics, LLC
InventorsMaria Zannes, Vivienne I. Rebel, William E. Bauta
Life of this patent
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Abstract
A porphyrin compound of Formula III and composition made therefrom comprising a therapeutically effective dose of a porphyrin bound via a linker to an anti-cancer agent useful in treating cancer in a patient in need thereof or to treat cancer cells in-vitro. The compounds and compositions may be delivered by a drug delivery device as disclosed here and be part of a kit.
Claims4
A compound of Formula III
- or a pharmaceutically acceptable salt thereof, wherein
- an A1, A2, A3 and A4 are each covalently attached to a porphyrin ring of Formula III and A1, A2, A3, and A4 are independently selected from a substituted aromatic ring or a six membered heteroaromatic ring containing a single nitrogen atom at the 2, 3 or 4 position relative to the porphyrin ring;
- B1 is a covalent linker moiety which connects A1 to a cytotoxic agent Z1 and is selected from
- wherein n is selected from 1-12;
- and
- the Z1 is a cytotoxic agent selected from
3 more elements
Dependencies are inferred from the claim text.