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US 11,590,232 B2Granted
Bioconjugates of neuropeptides derivatives
AssigneesCentre National De La Recherche Scientifique, Universite Paris-Saclay
InventorsPatrick Couvreur, Jiao Feng, Sinda Lepetre-Mouelhi
Life of this patent
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Abstract
A bioconjugate comprising at least one neuropeptide covalently bond to at least one hydrocarbon compound of squalene structure.
Claims21
A bioconjugate comprising at least one neuropeptide covalently bond to at least one hydrocarbon compound of squalene structure (SQ), as represented as follows,
- wherein:
- m1 is 0,1,2,3,4,5,6,7,8, or 9, and
- m2 is 0,1,2,3,4,5,6,7,8, or 9,
- and wherein
- represents the bond to the at least one neuropeptide, and
- wherein the at least one neuropeptide has a C-terminal acid covalently bonded to the at least one hydrocarbon compound of squalene structure by using a dioxycarbonyl spacer or the at least one neuropeptide has a N-terminal amine covalently bonded to the at least one hydrocarbon compound of squalene structure by using a diglycolate spacer.
3 more elements
A pharmaceutical composition comprising a bioconjugate comprising at least one neuropeptide covalently bond to at least one hydrocarbon compound of squalene structure (SQ), as represented as follows,
- wherein:
- m1 is 0,1,2,3,4,5,6,7,8, or 9, and
- m2 is 0,1,2,3,4,5,6,7,8, or 9,
- and wherein
- represents the bond to the at least one neuropeptide, and
- wherein the at least one neuropeptide has a C-terminal acid covalently bonded to the at least one hydrocarbon compound of squalene structure by using a dioxycarbonyl spacer or the at least one neuropeptide has a N-terminal amine covalently bonded to the at least one hydrocarbon compound of squalene structure by using a diglycolate spacer,
- as an active substance, and at least one pharmaceutically acceptable excipient and/or carrier.
4 more elements
Dependencies are inferred from the claim text.