Back to results
US 11,590,225 B2Granted
Bismuth-gadolinium nanoparticles
AssigneesThe Brigham and Women's Hospital, Inc., Nh Theraguix, Universite Claude Bernard Lyon 1, Centre National De La Recherche Scientifique
InventorsRoss Berbeco, Eloise Thomas, Francois Lux, Olivier Tillement, Alexandre Detappe, Geraldine Le Duc
Life of this patent
Estimating the term…
Abstract
Provided herein are nanoparticle compositions (e.g., nanoparticle compositions comprising high atomic number ions) that are useful for imaging diseases in a subject as well as radiosensitizing a disease in a subject (e.g., radiosensitizing a cancer in the subject). Methods of imaging a subject, methods of treating cancer, and processes of preparing the nanoparticle compositions are also provided.
Claims9
A composition, comprising:
- a nanoparticle core comprising one or more first linking groups covalently bonded to a first ligand and one or more second linking groups covalently bonded to a second ligand;
- wherein one or more of the first ligands are complexed to Gd3+ ions and one or more of the second ligands are complexed to Bi3+ ions,
- wherein the nanoparticle core is a silica core or a polysiloxane core,
- wherein the first ligand is selected from 1,4,7,10-tetraazacyclododececane, 1-(glutaric acid)-4,7,10-triacetic acid (DOTAGA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and the second ligand is selected from 1,4,7,10-tetraazacyclododececane, 1-(glutaric acid)-4,7,10-triacetic acid (DOTAGA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA);
- and
- wherein the composition comprises a ratio of Gd3+ ions:Bi3+ ions of from about 1:1 to about 2:1.
3 more elements
Dependencies are inferred from the claim text.