Antibodies that bind human C6 and uses thereof
AssigneeRegenesance B.V.
InventorsFrank Baas, Marc A. Van Dijk
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Abstract
Isolated monoclonal antibodies that bind to human complement component C6 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic methods for using the antibodies.
Claims8
A method of inhibiting membrane attack complex (MAC) formation or activity in a subject, the method comprising administering to the subject an antibody in an amount effective to inhibit MAC formation or activity in the subject, wherein the antibody comprises heavy chain CDR1, 2 and 3 sequences shown in SEQ ID NOs:
- 6, 7 and 8, respectively, and light chain CDR1, 2 and 3 sequences shown in SEQ ID NOs:
- 11, 12 and 13, respectively.
A method of reducing symptoms of a disorder mediated by MAC formation or activity in a subject, the method comprising administering to the subject an effective amount of an antibody, wherein the antibody comprises heavy chain CDR1, 2 and 3 sequences shown in SEQ ID NOs:
- 6, 7 and 8, respectively, and light chain CDR1, 2 and 3 sequences shown in SEQ ID NOs:
- 11, 12 and 13, respectively.
Dependencies are inferred from the claim text.