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AssigneeInstitute of Microbiology, Chinese Academy of Sciences
InventorsLianpan Dai, Jinghua Yan, Fu Gao, Yan Li, Tianyi Zheng, Kun Xu, Mei Liu, Yaling An, Yi Shi
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The embodiments of the present disclosure relate to antigens of β-coronaviruses, preparation methods and uses thereof. The amino acid sequence of the antigen of the β-coronavirus includes an amino acid sequence arranged in a (A-B)-(A-B) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B) pattern or an amino acid sequence arranged in a (A-B)-(A-B′) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B′) pattern. The antigen of the β-coronavirus has a single-chain dimer structure. A single-chain dirtier expressed according to examples of the present disclosure is stable in content and has excellent immunogenicity as an antigen of a β-coronavirus, and a vaccine prepared by using the single-chain dimer as an antigen of a β-coronavirus can elicit high-titer neutralizing antibodies in mice.
An antigen of a β-coronavirus, its amino acid comprising an amino acid sequence arranged in a (A-B)-(A-B) pattern or an amino acid sequence arranged in a (A-B)-C -(A-B) pattern or an amino acid sequence arranged in a (A-B)-(A-B′) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B′) pattern, wherein A-B represents a partial amino acid sequence or an entire amino acid sequence of a receptor binding domain of a surface spike protein of the β-coronavirus;
Dependencies are inferred from the claim text.