Combination immunotherapy compositions against cancer and methods
AssigneesGlobelImmune, Inc., The USA, as represented by the Secretary, Dept. of Health and Human Services
InventorsJames Hodge, Jeffrey Schlom, Alex Franzusoff
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Abstract
Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
Claims40
A method to prevent or treat at least one symptom of a disease or condition in an individual, comprising administering two immunotherapy compositions within a dosing period, the two immunotherapy compositions comprising:
- a) a first immunotherapy composition comprising a recombinant Ad5 adenovirus comprising a nucleic acid sequence encoding one or more peptides;
- and
- b) a second immunotherapy composition comprising one or more peptides and either a whole inactivated yeast or yeast lysate;
- wherein the one or more peptides of the first and second immunotherapy compositions are derived from the same one or more proteins.
A method to induce a therapeutic immune response against one or more proteins in an individual, comprising administering two immunotherapy compositions within a dosing period, the two immunotherapy compositions comprising:
- a) a first immunotherapy composition comprising a recombinant Ad5 adenovirus comprising a nucleic acid sequence encoding at least one peptide;
- and
- b) a second immunotherapy composition comprising at least one peptide and either a whole inactivated yeast or yeast lysate;
- wherein the peptides of the first and second immunotherapy compositions are derived from the same one or more proteins.
Dependencies are inferred from the claim text.