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US 11,590,213 B2Granted
Targeted expansion of Qa-1-peptide-specific regulatory CD8 T cells to ameliorate arthritis
AssigneeDana-Farber Cancer Institute, Inc.
InventorsHarvey Cantor, Hye-Jung Kim, Jianmei Wu Leavenworth
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Abstract
Nanoparticles to treat autoimmune diseases and HIV infection are provided. The nanoparticles comprise a biocompatible polymer and a complex, wherein the complex is a major histocompatibility complex (MHC) class I antigen E (HLA-E) linked to a peptide, and wherein the HLA-E-peptide complex is linked to the surface of the nanoparticle. The present invention also relates to methods for treating autoimmune diseases and HIV infection.
Claims15
A method for treating an autoimmune disease comprising:
- administering to a subject in need of such treatment a nanoparticle comprising a biocompatible polymer and a complex in an amount effective to ameliorate a symptom of the autoimmune disease,
- wherein the complex is a major histocompatibility complex (MHC) class 1 antigen E (HLAE) linked to a peptide,
- wherein the HLA-E peptide complex is linked to the surface of the nanoparticle, and
- wherein the peptide comprises Hsp60p216 or FL9.
1 more element
Dependencies are inferred from the claim text.