Method of treatment ovarian cancer
AssigneeHudson Institute of Medical Research
InventorsPaul Hertzog, Zoe Marks, Nollaig Bourke, Sn Sui Lim, Nicole De Weerd, Niamh Mangan, Antony Matthews
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Abstract
The invention is directed to methods of treating cancers using Interferon-ε (IFN-ε), wherein the IFN-ε includes various natural, synthetic and recombinant IFN-ε in compositions.
Claims18
A method for inhibiting replication, growth, development, motility, proliferation, survival, and/or migration of an ovarian cancer cell in a subject or of ovarian cancer metastases, said method comprising exposing the ovarian cancer cell or metastases to an amount of interferon epsilon (IFNε) effective to directly or indirectly induce apoptosis of the ovarian cancer cell or metastases, wherein the IFNε has at least 80% sequence identity to SEQ ID NO:
- 28 or SEQ ID NO:
- 32 and has INFε activity.
A method of treating a subject with ovarian cancer or ovarian cancer metastases, the method comprising administering to the subject an effective amount of IFNε to directly or indirectly induce apoptosis of an ovarian cancer cell;
- or inhibit replication, growth, development, motility, proliferation, survival and/or migration of a ovarian cancer cell or an ovarian cancer metastasis, wherein the IFNε has at least 80% sequence identity to SEQ ID NO:
- 28 or SEQ ID NO:
- 32 and has IFNε activity.
Dependencies are inferred from the claim text.